MedChemBench (Internal)

OpenAI's own drug-discovery test: reading chemical structures, predicting how potent or toxic a compound will be, choosing between candidate molecules, and planning a synthesis route — the everyday judgement calls of a medicinal chemist. Higher is better.

GPT-6 Astra by OpenAI holds the best MedChemBench (Internal) result among tracked models, at 49.7% (released Sep 3 2026). Higher scores are better on this benchmark.

1. GPT-6 Astra (OpenAI) — 49.7%.

1 tracked model has a published MedChemBench (Internal) score. Scores are collected from published lab reports and benchmark sources, with recorded sources credited alongside the results. We do not re-run the evaluations.