De novo binder design (24 hr)

de novo protein binder design within a 24-hour budget, as reported by Anthropic

Claude Mythos 5.2 by Anthropic holds the best De novo binder design (24 hr) result among tracked models, at 85.1% (released Nov 9 2026). Higher scores are better on this benchmark.

1. Claude Mythos 5.2 (Anthropic) — 85.1%; 2. Claude Mythos 5.1 (Anthropic) — 79.1%.

2 tracked models have a published De novo binder design (24 hr) score. Scores are collected from published lab reports and benchmark sources, with recorded sources credited alongside the results. We do not re-run the evaluations.